SAJE started working in the S-nitrosoglutathione reductase (GSNOR) field in 2011 after acquiring from Indiana University an exclusive license to a patent application on GSNOR inhibiting technology. That patent has since issued in the US and the EPO and protects the use of SAJE’s first generation small molecule compound, SPL-334, for a number of inflammatory diseases including: asthma, COPD, IPF, cystic fibrosis, Crohn’s disease, and inflammatory bowel disease.
Since acquiring that first patent, SAJE has considerably strengthened its IP portfolio. The Company started its own chemistry discovery program at its laboratory at the University of Illinois Incubator in Chicago. To date, that program has discovered three novel core structures that have been elaborated to produce numerous second and third generation GSNOR inhibitors that are novel compositions of matter with nanomolar IC50’s, potent therapeutic activity, oral, and in some cases, brain bioavailability.
On 26 February 2016, SAJE filed a patent application on its first core structure claiming composition of matter and therapeutic uses for many compounds derived from it. The structures were derived from structure-activity relationships for the GSNOR active site and are proprietary to SAJE. More patent applications in that series will be filed shortly. At the same time, we are continuing to work on compounds derived from the second and third core structures and will file composition applications based on them at the appropriate time.
SAJE is working with some of the best pharmaceutical patent attorneys in the United States to handle its IP. Those attorneys are from the patent firm of Foley & Lardner LLP in the San Diego and Palo Alto, CA offices.